No. Any update to any of the dependencies of a cell will cause its downstream cells to be invalidated. You can read more about it here:
Note however that Observable’s Runtime cannot account for global variables or other side effects.
I’d argue that’s an advanced usage pattern, but I also responded to that already: await for specific cell value - #11 by mootari
Also an advanced usage pattern, and basically a vanilla JS throttling problem. If you want to go the extra mile, then the only addition here would be that a queued request might become invalid before it gets sent.
A simple implementation would look like this: